Several precautions are necessary to ensure the safety of neonates under general anesthesia. Preoperative assessments are crucial to identify any underlying conditions that could increase the risk of complications. Intraoperatively, maintaining normothermia is critical, as neonates can easily become hypothermic. Fluid management, blood glucose levels, and electrolytes must be closely monitored. Additionally, the anesthesia team must be prepared to manage any airway complications or hemodynamic instability promptly.