What Role Do Genetics Play in Denys-Drash Syndrome?
DDS is caused by mutations in the WT1 gene, which is located on chromosome 11. This gene is essential for normal kidney and gonadal development. Mutations in WT1 disrupt its function, leading to the characteristic symptoms of DDS. Genetic counseling is recommended for families affected by DDS to understand the inheritance pattern and risks for future pregnancies.
