What Are the Clinical Implications of Immature Kidney Function?
Immature kidney function can have several clinical implications, including: - Fluid Overload: Due to reduced GFR, neonates are at higher risk for fluid overload, which can lead to conditions such as pulmonary edema. - Electrolyte Imbalance: The kidneys play a vital role in maintaining electrolyte balance. Immature kidneys may not effectively regulate sodium, potassium, and calcium levels, leading to imbalances. - Drug Clearance: Reduced renal clearance can lead to the accumulation of drugs that are primarily excreted via the kidneys, increasing the risk of drug toxicity.
