The primary symptom of erythema migrans is the appearance of the characteristic rash, which usually develops 3 to 30 days after a tick bite. The rash starts as a small red spot that gradually expands over several days. It can be warm to the touch but is usually not painful or itchy. In addition to the rash, children may experience symptoms such as fever, fatigue, headache, muscle and joint aches, and swollen lymph nodes.