How Does Immature Liver Function Affect Drug Metabolism?
The liver is essential for the metabolism of many medications. In neonates, the activity of cytochrome P450 enzymes, which are responsible for drug metabolism, is significantly reduced. This can lead to prolonged drug half-lives and increased risk of toxicity. For example, the metabolism of drugs like acetaminophen and morphine is slower in neonates, necessitating careful dosing and monitoring.
