In pediatrics, the role of RISC is particularly important due to its involvement in the regulation of genes that are crucial for early development, differentiation, and growth. Abnormalities in the function of RISC can lead to various pediatric diseases and developmental disorders. For example, dysregulation of miRNA and the RISC pathway has been linked to conditions such as congenital heart defects, neurodevelopmental disorders, and certain types of pediatric cancers.