formulation issues

Why is Pediatric Formulation Challenging?

Formulating medications for pediatric use poses unique challenges due to various physiological, psychological, and developmental differences between children and adults. The anatomical and physiological differences, such as gastric pH, enzyme activity, and body composition, can affect drug absorption, distribution, metabolism, and excretion. Moreover, children's taste preferences and swallowing capabilities differ significantly from adults, necessitating specialized formulations that are both effective and palatable.

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