What are the Key Considerations in Pediatric Formulation?
Several key factors need to be considered when developing pediatric formulations:
1. Dosage Form: Common dosage forms such as tablets and capsules may not be suitable for young children who have difficulty swallowing pills. Liquid formulations, chewable tablets, and dispersible tablets are often preferred. 2. Taste and Palatability: Unpleasant tastes can lead to non-compliance. Sweeteners, flavorings, and taste-masking techniques are frequently used to improve the palatability of pediatric medications. 3. Safety and Efficacy: Ensuring the safety and efficacy of medications in children often requires specific clinical trials. Dosing regimens need to be carefully calculated based on age, weight, and developmental stage. 4. Excipients: Some excipients used in adult formulations can be harmful to children. For instance, benzyl alcohol and propylene glycol can cause toxicity in neonates.
