Therapeutic failure can occur due to various factors, including:
- Incorrect diagnosis: An incorrect diagnosis can lead to inappropriate treatment, ultimately resulting in therapeutic failure. - Drug resistance: Pathogens may develop resistance to the prescribed medication, rendering it ineffective. - Inadequate dosing: Due to the unique pharmacokinetics in neonates, dosing errors can easily occur. Both underdosing and overdosing can result in therapeutic failure. - Non-compliance: In some cases, caregivers may not adhere to the treatment regimen, causing suboptimal outcomes. - Drug interactions: Neonates are often on multiple medications, increasing the risk of drug interactions that can reduce effectiveness or cause adverse effects.
