Bicarbonate therapy is primarily indicated in neonates with significant metabolic acidosis. Common scenarios include:
1. Severe Metabolic Acidosis: When blood pH falls below 7.2 and bicarbonate levels are critically low. 2. Neonatal Asphyxia: Infants who have experienced birth asphyxia often develop acidosis due to hypoxia and impaired circulation. 3. Sepsis: This condition can lead to metabolic acidosis due to poor tissue perfusion and increased lactic acid production. 4. Renal Tubular Acidosis: Infants with impaired kidney function may struggle to maintain acid-base balance. 5. Congenital Heart Disease: Certain heart defects can lead to poor oxygenation and acidosis.
