What Pediatric Conditions Could Potentially Benefit from Histone Demethylase Inhibitors?
Research is ongoing, but several pediatric conditions could potentially benefit from histone demethylase inhibitors:
- Pediatric Cancers: Conditions like neuroblastoma, medulloblastoma, and certain leukemias have shown aberrant histone methylation patterns. Histone demethylase inhibitors could play a role in reprogramming the cancer cells to a less aggressive state. - Genetic Disorders: Some genetic disorders involve mutations in genes encoding histone demethylases. Inhibiting these enzymes might help in correcting the gene expression abnormalities caused by these mutations. - Neurodevelopmental Disorders: While still in the early research stages, there is potential for histone demethylase inhibitors to address some forms of intellectual disability and autism spectrum disorders by modulating gene expression patterns involved in brain development.
