Histone demethylase inhibitors function by binding to the active site of histone demethylases, thereby preventing these enzymes from removing methyl groups from histone proteins. This inhibition can lead to an accumulation of specific methylation marks on histones, which in turn can alter the expression of genes involved in cell growth, differentiation, and survival. The precise mechanisms can vary depending on the specific inhibitor and the histone demethylase it targets.
