MSP has utility in diagnosing several pediatric conditions, including:
Pediatric cancers: Aberrant methylation patterns are often observed in childhood cancers like neuroblastoma, Wilms' tumor, and acute lymphoblastic leukemia (ALL). Congenital disorders: Conditions such as Prader-Willi syndrome and Angelman syndrome are linked to abnormal methylation. Neurodevelopmental disorders: Disorders like Rett syndrome and Fragile X syndrome have characteristic methylation changes.
