The primary treatment for neonatal HSV is intravenous acyclovir. The duration of treatment depends on the type of infection:
- SEM Disease: Typically treated for 14 days. - CNS Disease: Requires a minimum of 21 days. - Disseminated Disease: Also treated for at least 21 days.
After completion of intravenous treatment, oral acyclovir is often recommended for several months to prevent relapse, especially in cases involving CNS disease.
