What is Multiplex Ligation Dependent Probe Amplification (MLPA)?
Multiplex Ligation Dependent Probe Amplification (MLPA) is a sensitive, high-throughput technique used for detecting copy number variations (CNVs) in DNA sequences. It is particularly useful in identifying deletions and duplications, which are common in various genetic disorders. The technique relies on the ligation of specific probes to target sequences, followed by amplification and quantification, allowing for the precise measurement of DNA copy numbers.
