Li-Fraumeni Syndrome (LFS) is a rare, inherited disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults. It is caused by mutations in the TP53 gene, which plays a crucial role in controlling cell division and apoptosis. Individuals with LFS have a predisposition to multiple cancer types, including sarcomas, breast cancer, brain tumors, adrenocortical carcinomas, and leukemias.