Hypoxic Ischemic Encephalopathy (HIE) is a type of brain dysfunction that occurs when the brain experiences a reduction in blood flow and oxygen supply. This condition is particularly concerning in the context of neonatal disorders, as it can lead to severe and long-lasting impairments in newborns. HIE is a significant cause of neonatal mortality and long-term neurological disabilities, including cerebral palsy, developmental delays, and cognitive impairments.