What Factors Influence Volume of Distribution in Pediatric Patients?
Several factors can influence the Vd in pediatric patients:
Age: Vd changes as children grow, which necessitates age-specific dosing guidelines. Body Weight: Body weight is a critical determinant in calculating Vd and subsequent drug dosing. Organ Function: Kidney and liver functions, which are not fully developed in neonates and infants, can affect drug metabolism and excretion. Protein Binding: Lower plasma protein levels in newborns affect the binding of drugs, altering the Vd.
