Several factors must be considered when adjusting doses for pediatric patients:
Age: Neonates, infants, toddlers, and adolescents all have different pharmacokinetic profiles. Weight: Many pediatric doses are calculated on a mg/kg basis. Body Surface Area (BSA): Some medications use BSA-based dosing, especially in chemotherapy. Organ Function: Immature liver and kidney function in neonates and infants can affect drug metabolism and excretion. Developmental Stage: Growth spurts and puberty can alter drug pharmacokinetics.
