There are three main types of Pompe disease, classified based on the age of onset and severity of symptoms:
Classic infantile-onset Pompe disease appears within a few months after birth and is the most severe form. It is characterized by heart and muscle problems, including hypertrophic cardiomyopathy and profound muscle weakness. Non-classic infantile-onset Pompe disease usually manifests within the first year of life but is less severe than the classic form. Symptoms include muscle weakness and delayed motor skills, with less pronounced heart involvement. Late-onset Pompe disease can appear in childhood, adolescence, or adulthood. The primary symptoms are progressive muscle weakness and respiratory difficulties.
