Symptoms can vary depending on the type of HSV infection: - Localized Skin, Eye, and Mouth (SEM) Disease: Characterized by vesicular lesions on the skin, eyes, or mouth, typically appearing between 1-2 weeks of age. - Central Nervous System (CNS) Disease: Symptoms include lethargy, irritability, seizures, and poor feeding. This form of HSV can lead to encephalitis. - Disseminated Disease: Involves multiple organs and can present with symptoms such as jaundice, bleeding, respiratory distress, and shock. This form is the most severe and can be fatal if not treated promptly.