While glycerin is generally safe, it can cause some side effects, especially if used improperly. Common side effects of glycerin suppositories include rectal discomfort, burning sensation, or mild cramping. Overuse can lead to dependency on laxatives, so it is crucial to use glycerin suppositories only occasionally and under a pediatrician's guidance. In skin care products, glycerin is usually well-tolerated, but in rare cases, it may cause allergic reactions or skin irritation.
