What are the Mechanisms Behind Apoptosis in Neonatal Disorders?
The mechanisms behind apoptosis in neonatal disorders can be multifactorial. Common triggers include oxidative stress, inflammation, and genetic mutations. For instance, in HIE, oxidative stress leads to mitochondrial dysfunction and the release of cytochrome c, which activates the intrinsic apoptotic pathway. In NEC, bacterial infections can induce inflammatory cytokines that activate the extrinsic apoptotic pathway.
