What are the Key Factors in Pediatric Drug Selection?
Several factors must be taken into account when selecting drugs for pediatric patients:
Age: The age of the child can significantly influence drug absorption, distribution, metabolism, and excretion. Newborns, infants, toddlers, and adolescents all have different pharmacokinetic profiles. Dose Adjustments: Dosages often need to be adjusted based on the child's weight and body surface area. It is crucial to avoid both underdosing and overdosing. Formulation: The formulation of the drug (e.g., liquid, chewable, or tablet) must be appropriate for the child's age and ability to swallow pills. Safety Profile: Children are more susceptible to certain side effects and toxicities. Therefore, the safety profile of the drug must be thoroughly evaluated. Compliance: Ensuring that children adhere to their medication regimen can be challenging. Palatability and ease of administration play important roles in compliance.
