What are the Common Neonatal Disorders Related to PTH?
Several neonatal disorders can be associated with abnormal PTH levels. These include:
1. Neonatal Hypocalcemia: This condition is characterized by low levels of calcium in the blood. It can be early-onset (within the first 72 hours of life) or late-onset (after the first week). Causes include maternal diabetes, prematurity, and perinatal asphyxia. PTH deficiency or resistance can also lead to hypocalcemia.
2. Neonatal Hyperparathyroidism: This rare condition involves excessive production of PTH, leading to high levels of calcium in the blood (hypercalcemia). It can be due to genetic mutations affecting the calcium-sensing receptor or other underlying conditions.
3. Pseudohypoparathyroidism: This disorder involves resistance to the action of PTH. Despite normal or elevated PTH levels, the neonate's body fails to respond appropriately, resulting in hypocalcemia and hyperphosphatemia.
