To minimize gastrointestinal discomfort, doxycycline should be taken with food or a full glass of water. It is also advisable to avoid taking the medication just before lying down to prevent esophageal irritation. Additionally, children should be advised to wear [sunscreen](https:// "Sunscreen") and protective clothing when outdoors due to the increased risk of [photosensitivity](https:// "Photosensitivity").
