The use of doxycycline in children under the age of 8 is generally avoided because of the risk of permanent [tooth discoloration](https:// "Tooth Discoloration") and enamel hypoplasia. This antibiotic can bind to calcium ions in the teeth, leading to yellow, gray, or brown staining. Therefore, its use is restricted to instances where the benefits outweigh the risks, such as in the treatment of life-threatening infections where no suitable alternative is available.
