Diagnosis involves a combination of clinical evaluation and laboratory testing:
Clinical Evaluation: A thorough physical examination and medical history are essential. Serologic Tests: These include non-treponemal tests (e.g., VDRL and RPR) and treponemal tests (e.g., FTA-ABS and TP-PA). Positive results must be confirmed with specific tests. Direct Detection: Darkfield microscopy or PCR can detect the presence of Treponema pallidum in lesions or body fluids.
