The dosage and route of administration of paracetamol in neonates are critical. It can be administered orally, rectally, or intravenously. The dose is usually weight-based, typically ranging from 10-15 mg/kg per dose, administered every 4-6 hours, not exceeding four doses in 24 hours. Intravenous administration is reserved for cases where oral or rectal routes are not feasible.