What are the Pharmacokinetics of Paracetamol in Neonates?
Neonates exhibit different pharmacokinetics compared to older children and adults. The drug's absorption, distribution, metabolism, and excretion can vary. Neonates have a reduced capacity to metabolize paracetamol due to immature liver enzymes, particularly glucuronyl transferase. This necessitates cautious dosing and monitoring.
