The diagnosis of neonatal cholestasis typically involves a combination of clinical evaluation, laboratory tests, and imaging studies. Initial laboratory tests include:
- Liver function tests: Elevated levels of direct (conjugated) bilirubin, alkaline phosphatase, and gamma-glutamyl transferase (GGT). - Serologic tests: To rule out infections like CMV and hepatitis. - Genetic testing: For inherited conditions.
Imaging studies such as ultrasonography and hepatobiliary scintigraphy can help identify structural abnormalities like biliary atresia.
