The FISH procedure typically involves several steps:
Sample preparation: Cells are collected from the neonate, often from blood or tissue samples. Probe labeling: DNA probes are labeled with fluorescent dyes. Hybridization: Probes are mixed with the sample and allowed to bind to their complementary DNA sequences on the chromosomes. Visualization: The sample is examined under a fluorescence microscope, where the bound probes emit light, highlighting the targeted regions.
