Calculating a loading dose involves several factors:
Patient's weight or body surface area. The volume of distribution (Vd) of the drug, which indicates how extensively a drug disperses into body tissues. The desired plasma concentration (Cp) of the medication.
The formula generally used is: Loading Dose = (Cp x Vd) / Bioavailability. Adjustments may be necessary based on the child's clinical condition and response to the medication.