Neonatal sepsis is a severe infection in newborns that can lead to systemic inflammation. TNF Alpha is one of the early cytokines released in response to infection. It helps to recruit other immune cells to the site of infection and activates them to destroy pathogens. However, excessive production of TNF Alpha can lead to overwhelming inflammation, resulting in tissue damage, organ failure, and potentially death. Monitoring TNF Alpha levels can be useful for early diagnosis and management of neonatal sepsis.