Choline - Neonatal Disorders

What is Choline?

Choline is an essential nutrient that plays a significant role in many physiological processes. It is a water-soluble compound that is similar to the B vitamins. Choline is vital for neurotransmitter synthesis, cell membrane structure, and lipid transport and metabolism. It is especially important for brain development and function, making it crucial in the field of pediatrics.

Why is Choline Important for Children?

In growing children, choline is essential for cognitive development and brain health. It supports the formation of the myelin sheath, which insulates nerve fibers and enhances the speed of neural transmission. Adequate choline intake is linked to better memory, learning abilities, and overall cognitive function.

What are the Recommended Daily Intakes of Choline for Children?

The Institute of Medicine provides guidelines for adequate intake (AI) levels of choline for different age groups:

Infants 0-6 months: 125 mg/day
Infants 7-12 months: 150 mg/day
Children 1-3 years: 200 mg/day
Children 4-8 years: 250 mg/day
Children 9-13 years: 375 mg/day

What are Good Dietary Sources of Choline?

Choline is found in a variety of foods, making it relatively easy to include in a child's diet. Some excellent sources include:

Eggs
Meat and poultry
Fish
Dairy products
Cruciferous vegetables like broccoli and Brussels sprouts
Legumes
Nuts and seeds
Whole grains

What are the Consequences of Choline Deficiency in Children?

Choline deficiency can lead to several health issues. In children, a lack of choline can impair brain development and cognitive performance. It may also lead to muscle damage and liver dysfunction. Ensuring adequate choline intake is thus critical for a child's overall development and well-being.

Can Choline be Supplemented?

While it's generally best to obtain nutrients through a balanced diet, choline supplements are available for those who may not get enough from food alone. It is advisable to consult a healthcare provider before giving any nutritional supplements to children, as excessive choline intake can cause adverse effects like fishy body odor, vomiting, and low blood pressure.

How Can Parents Ensure Adequate Choline Intake for Their Children?

Parents can ensure their children receive adequate choline by providing a balanced diet that includes choline-rich foods. Monitoring and planning meals with a variety of proteins, vegetables, and grains can help meet daily choline requirements. If dietary sources are insufficient, consulting a pediatrician is essential for personalized advice and potential supplementation.

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Influence of deep eutectic solvents on redox biocatalysis involving alcohol dehydrogenases.

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Dietary choline intake in European and non-european populations: current status and future trends-a narrative review.

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Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.

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Modeling brain pathology to study nose-to-brain drug delivery.

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Reduced preoperative serum choline esterase levels and fecal peritoneal contamination as potential predictors for the leakage of intestinal sutures after source control in secondary peritonitis.

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Autophagy markers LC3 and p62 in aging lumbar motor neurons.

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α7 Nicotinic Receptor Activation Mitigates Herpes Simplex Virus Type 1 Infection in Microglia Cells.

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Biorefinery approach with green solvents for the valorization of Citrus reticulata leaves to obtain antioxidant and anticholinergic extracts.

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Comparative genomic and metabolomic analysis reveals the potential of a newly isolated Enterococcus faecium B6 involved in lipogenic effects.

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Ultrasound-assisted deep eutectic solvents extraction of polysaccharides from Loquat leaf: Process optimization and bioactivity study.

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An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD).

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Detection of early-stage NASH using non-invasive hyperpolarized C metabolic imaging.

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Production of non-natural terpenoids through chemoenzymatic synthesis using substrate analogs.

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Community metabolic modeling of host-microbiota interactions through multi-objective optimization.

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Impregnation of Silica Gel with Choline Chloride-MEA as an eco-friendly adsorbent for CO capture.

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Unveiling Dissolution Kinetics of CuO Nanofertilizer Using Bio-Based Ionic Liquids Envisaging Controlled Use Efficiency for Sustainable Agriculture.

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A Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease.

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ML Models Built Using Clinical Parameters and Radiomic Features Extracted from F-Choline PET/CT for the Prediction of Biochemical Recurrence after Metastasis-Directed Therapy in Patients with Oligometastatic Prostate Cancer.

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