PGE1 is crucial in the management of neonates with congenital heart defects that depend on a patent ductus arteriosus (PDA) for adequate pulmonary or systemic blood flow. Conditions such as hypoplastic left heart syndrome, transposition of the great arteries, and tetralogy of Fallot are examples where PGE1 is lifesaving. By keeping the ductus arteriosus open, PGE1 ensures adequate mixing of oxygenated and deoxygenated blood, improving oxygen delivery to tissues.
