In pediatrics, the proper functioning of Dicer is essential for normal development. Abnormalities in Dicer activity can lead to a range of developmental disorders and diseases. For instance, mutations in the Dicer gene have been linked to DICER1 syndrome, which is associated with a predisposition to various tumors in children such as pleuropulmonary blastoma, cystic nephroma, and ovarian sex cord-stromal tumors.