Neonates, especially preterm infants and those with low birth weight, have underdeveloped immune systems, making them more susceptible to infections. The immune system of a neonate is not fully matured, and the skin and mucous membranes, their first line of defense, are also less effective barriers. Additionally, extended hospital stays and the use of invasive devices like central venous catheters can introduce the pathogen into the bloodstream, increasing the risk of aspergillosis.
