Several factors contribute to the increased susceptibility of neonates to infections:
- Immature Immune Response: Neonates have an underdeveloped adaptive immune system, leading to a reduced ability to produce specific antibodies and mount effective responses to pathogens. - Limited Exposure: A lack of prior exposure to pathogens means that neonates have not developed immunological memory. - Barrier Functions: The skin and mucosal barriers, which serve as first-line defenses, are not fully developed at birth, making it easier for pathogens to enter the body.
