WGS should be considered in the following situations: 1. Unexplained Symptoms: When a child presents with symptoms that cannot be explained by standard diagnostic tests. 2. Family History: If there is a known family history of genetic disorders, WGS can clarify the risk to the child. 3. Neonatal Screening: In some cases, WGS can be used as part of newborn screening programs to identify genetic conditions early. 4. Research Participation: Families may choose to participate in research studies that use WGS to understand pediatric diseases better.
