Several factors influence Vd in pediatric patients:
- Body Composition: Infants have a higher total body water content and lower fat stores, altering drug distribution. - Protein Binding: Neonates have lower levels of plasma proteins like albumin, which can impact the binding and, consequently, the Vd of drugs. - Organ Maturity: The maturation of the liver and kidneys affects drug metabolism and excretion, which in turn can influence Vd. - Disease States: Conditions such as dehydration, malnutrition, or diseases affecting liver and kidney function can alter Vd.
