What are the Challenges in Determining Vd in Pediatrics?
Several challenges exist in determining Vd in pediatric patients:
- Ethical Concerns: Conducting pharmacokinetic studies in children poses ethical challenges, limiting available data. - Variability: Significant inter-individual variability in growth and development complicates standardization of Vd measurements. - Limited Data: Many drugs are not extensively studied in pediatric populations, leading to a reliance on extrapolation from adult data.
