Several factors contribute to the vulnerability of neonates. Premature birth is one of the most significant factors. Premature infants, born before 37 weeks of gestation, have underdeveloped organs and are prone to complications such as respiratory distress syndrome, intraventricular hemorrhage, and necrotizing enterocolitis. Low birth weight, defined as a weight of less than 2500 grams at birth, also places infants at higher risk for health issues.