What Conditions Lead to Elevated Direct Bilirubin in Pediatrics?
Several conditions can result in elevated direct bilirubin levels in children:
- Neonatal Cholestasis: This condition involves the reduction or stoppage of bile flow and can be due to various causes like biliary atresia, Alagille syndrome, or progressive familial intrahepatic cholestasis. - Infections: Hepatitis, sepsis, and other infections can impair liver function and elevate direct bilirubin. - Metabolic Disorders: Conditions such as galactosemia, tyrosinemia, and alpha-1 antitrypsin deficiency can lead to liver dysfunction and increased direct bilirubin levels. - Genetic Conditions: Disorders like Dubin-Johnson syndrome and Rotor syndrome are rare but can cause elevated direct bilirubin due to issues with bilirubin transport and excretion.
