Despite its potential benefits, there are several concerns associated with ketamine use in neonates:
- Neurotoxicity: Animal studies have raised concerns about ketamine-induced neurotoxicity, especially with prolonged or high-dose exposure. The developing brain is particularly vulnerable, and the long-term effects on cognitive function remain uncertain.
- Respiratory Effects: While generally safer than other anesthetics in terms of respiratory function, ketamine can still cause respiratory depression, particularly in higher doses.
- Psychological Effects: The dissociative properties of ketamine may lead to hallucinations or other psychological effects. While this is more of a concern in older children and adults, it is an area that requires further research in neonates.
