Several factors can contribute to neonatal brain damage, including: - Hypoxia: Insufficient oxygen supply during birth. - Infections: Maternal infections like Group B Streptococcus or Herpes Simplex Virus. - Trauma: Physical trauma during delivery. - Prematurity: Premature infants are at higher risk due to underdeveloped organs. - Genetic Disorders: Conditions such as metabolic disorders and congenital malformations.