What are the Treatment Options for NPHS2-related SRNS?
Treatment for SRNS caused by mutations in the NPHS2 gene can be challenging. Since the condition is resistant to steroids, other immunosuppressive therapies such as calcineurin inhibitors (e.g., cyclosporine or tacrolimus) are often used. Supportive treatments, including ACE inhibitors or ARBs, can help reduce proteinuria. In severe cases, kidney transplantation may be necessary.