whole exome sequencing (wes)

What are the Limitations of WES?

Despite its advantages, WES has some limitations:
Incomplete Coverage: Some exons may not be adequately covered, leading to missed mutations.
Variants of Uncertain Significance: WES can identify variants whose clinical significance is unclear, leading to uncertainty in diagnosis.
Incidental Findings: WES may uncover unrelated genetic findings, raising ethical and counseling challenges.
Limited Detection: WES may not detect certain types of mutations, such as large deletions or duplications.

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