Several key enzymes are involved in Phase II metabolism: - UDP-glucuronosyltransferases (UGTs): Responsible for glucuronidation, these enzymes help conjugate bilirubin, hormones, and drugs. - Sulfotransferases (SULTs): Catalyze sulfation reactions, which are important for the metabolism of steroids, neurotransmitters, and drugs. - N-Acetyltransferases (NATs): Involved in acetylation, important for the metabolism of drugs like isoniazid. - Methyltransferases: Enzymes like catechol-O-methyltransferase (COMT) are responsible for methylation reactions.
