What Are the Challenges of Using RNAi in Pediatrics?
Despite its potential, RNAi faces several challenges such as:
Delivery Systems: Efficiently delivering RNAi molecules to target cells and tissues in a child's body remains a significant hurdle. Off-Target Effects: Unintended silencing of non-target genes can lead to adverse effects. Immune Response: The body’s immune system may react against RNAi molecules, reducing their efficacy. Long-term Safety: The long-term effects of RNAi in children are still not well understood.
